https://www.yahoo.com/lifestyle/know-covid-variants-eg-5-171441068.html
What to know about new COVID variants EG.5, FL.1.5.1 and BA.2.86 now spreading
Alexander Raths
Health authorities say they're closely tracking the spread of three new COVID-19 variants now spreading around the country.
Levels
of COVID-19 hospitalizations and deaths for now remain far below
previous peaks seen during past summer and winter waves of the virus,
but have been climbing steadily for several weeks.
Public
health officials have said that they're well-equipped for the latest
seasonal uptick in the virus, with COVID-19 tests and forthcoming
vaccines expected to work for the variants on the rise around the
country.
But the appearance of a new "highly mutated" variant has
raised questions among virus trackers about what the coming months could
hold.
Here's the latest about what we know about the new COVID-19 variants now on the rise.
What are current new COVID variants?
There
are two that are fairly prevalent and one — the highly mutated variant —
that is not as widespread, for now. Every two weeks, the Centers for
Disease Control and Prevention publishes projections of COVID-19 variants that are dominant around the country.
The
EG.5 variant is estimated to be the "dominant" strain in the U.S.
because it makes up the largest share of new cases of COVID-19 compared
to other variants. On Aug. 18, the CDC estimated EG.5 made up 20.6% of
new infections.
Behind EG.5 – unofficially nicknamed
"Eris" by virus tracker T. Ryan Gregory on social media – is a long
list of other closely related variants, virtually all of which descended
from the XBB strains that were dominant last winter.
FL.1.5.1 is
the next-largest strain at 13.3% of U.S. infections, the CDC estimated.
Dubbed "Fornax" by Gregory, FL.1.5.1 has nearly doubled from the week
prior when it was an estimated 7.1% of circulating variants.
Both EG.5 and FL.1.5.1 are XBB variant descendants that share a mutation known as F456L, which appears to be helping them spread more than other virus siblings.
Authorities
have also been tracking a new highly mutated strain of the virus called
BA.2.86. That strain was nicknamed "Pirola" by user @JPWeiland
on social media. BA.2.86's prevalence remains too small to show up on
the CDC estimates and is currently being aggregated with its distant
ancestor BA.2.
While only a small handful of cases have been spotted around the world, including one in Michigan,
the strain's large number of mutations at some key parts of the virus
has accelerated investigations into the risk that BA.2.86 might pose.
Are symptoms for new COVID variants different?
COVID
symptoms appear to be largely the same. Since EG.5 and FL.1.5.1
emerged, officials have generally downplayed claims of dramatic changes
in symptoms caused by these closely related new variants, compared to
their close Omicron variant relatives from earlier in the pandemic.
There has been no evidence of increased disease severity from the new EG.5 strain, the WHO reported on August 9.
Experts
say other changes in the population, like immunity from prior
infections and vaccination, also muddies attempts to compare whether new
variants are to blame for shifts in reported symptoms from the virus.
In
recent months, COVID-19 symptoms appear to have remained largely the
same as they have for the past year, with cold and flu-like signs –
cough, headache, muscle aches, runny nose and fatigue – reported most often.
As
for BA.2.86, officials say it is too early to say whether that strain
will cause more severe illness because of its worrying sum of mutations.
The
sole case in Michigan was "an older adult with mild symptoms, and [the
patient] has not been hospitalized," Chelsea Wuth, a spokesperson for
the state Department of Health and Human Services, said in a statement
to CBS News.
In Denmark, health officials said their three BA.2.86 variant cases did not have "symptoms other than those normally seen" from COVID-19.
The U.K. said
its BA.2.86 case was tested at a London hospital, but that it was
currently not possible "to assess comparative severity by variant" based
on their data.
Do COVID tests work for new COVID variants?
They
seem to work, although that may change if one of the strains becomes
more prevalent. The Food and Drug Administration has so far not flagged any new
issues with the EG.5 and FL.1.5.1 variants, from its ongoing joint
effort with the National Institutes of Health to study the performance
of COVID-19 tests with new strains. One positive development — Modeling
suggests the variant will not evade tests better than other previous
Omicron strains.
"Now we have the genome mapped and all that
information. We also have the epitopes mapped for all antigen-based
tests. We can do computational analytics to see whether or not we think
there's going to be any impact on test performance," Todd Merchak,
co-lead of the NIH's RADx Tech initiative at the National Institute of Biomedical Imaging and Bioengineering.
Merchak
said the initiative's "well-oiled machine" has been preparing for
manual experiments to validate whether home COVID tests are less
sensitive to EG.5 and other variants, in case the FDA decides to call
for home COVID tests to be rechecked for the new strains.
"We use
the same protocols, so we have comparisons across every test that's on
the market, every test that's in development, we can compare them
against each other so we have data for everything," said Merchak.
Experts say it's possible BA.2.86's wide changes might change the performance of some tests, if it grows more prevalent.
U.K.health authorities said
it was "unreliable to attempt to predict the combined effect of the
large number of mutations" from BA.2.86, but acknowledged there's enough
information "to expect significant antigenic change."
Will the fall 2023 COVID vaccine boosters work for new COVID variants?
They're
expected to be effective. Vaccine makers say they expect the upcoming
rollout of new COVID-19 vaccine and booster shots next month will work
for EG.5 and FL.1.5.1 as well, since they are closely related to the
XBB.1.5 variant targeted by the revised shots recommended by the FDA and WHOearlier this year.
"We
try to select the antigen that will provide the maximum breadth of
immunity so that the protection to people is as wide as possible,
anticipating that the virus may evolve between the time when the
recommendation is issued and the time when the vaccine is produced," the
WHO's Dr. Sylvie Briand told reporters on August 9.
On Aug. 17, Moderna said
preliminary results from its human clinical trial data suggest its
updated vaccines will trigger a "significant boost in neutralizing
antibodies against EG.5 and FL.1.5.1 variants." Pfizer says data from a
recent study in mice suggests its vaccine will be effective as well.
The
CDC expects, based on evidence and input from the FDA advisory
committee, that "the fall updated vaccines with a monovalent XBB.1.5
composition will best protect public health," Kathleen Conley, a CDC
spokesperson, said in a statement August 18.
It is unclear whether
BA.2.86 could upend those plans. Experts say the strain's mutations
might be enough to render the upcoming shots "a fairly poor match" if it circulates more widely.
But
for this season, the FDA does not see a need to change up the COVID
vaccine recipe, an official said. Another meeting of its outside vaccine
advisers on the topic isn't planned until preparation begins for next
year's vaccination campaign.
"Barring the emergence of a markedly
more virulent viral variant causing COVID-19, the FDA anticipates
revisiting the composition of the vaccine during the first half of
2024," the FDA official said in an Aug. 16 email.
